Computer and Modernization ›› 2013, Vol. 1 ›› Issue (2): 138-142.doi: 10.3969/j.issn.1006-2475.2013.02.034

• 应用与开发 • Previous Articles     Next Articles

Design of New Antimicrobial Peptides and Prediction of Its Activity and Function

YANG Li-min1, HUANG Yan1, ZHANG Ri-jun2   

  1. 1. College of Information and Electrical Engineering, China Agricultural University, Beijing 100083, China；2. Laboratory of Feed Biotechnology, State Key Lab. of Animal Nutrition, China Agricultural University, Beijing 100083, China
  • Received:2012-10-17 Revised:1900-01-01 Online:2013-02-27 Published:2013-02-27

Abstract: This paper determines the parameters of quantization factor through analyzing the impact of antimicrobial peptide activity factor. Then, it analyzes activity factor data of existing antimicrobial peptide, and obtains range of parameters. To get new peptide, it shears and links existing antimicrobial peptides’ sequence by using Java technology. At last, according to the parameter range it predicts activity and function of new peptide. At the same time, it builds the three-dimensional structure of antimicrobial peptide. The results show that net charge of four antimicrobial peptides is identical; however, it is essential to antibacterial activity. Hydrophobic residue% and α-helix% have significant effect on distinguishing four types of antimicrobial peptides.

Key words: α-helix, activity factors, activity prediction, function prediction, antimicrobial peptides, three-dimensional structure